Modification of mRNA by snoRNA‐guided 2′‐ O ‐methylation
نویسندگان
چکیده
منابع مشابه
2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase
RNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2'-O methyltransferase activities that are required for the formation of 5' type I cap (m(7)GpppAm) of viral RNA genome. Here we reported, for the first time, that flavivirus NS5 has a novel internal RNA methylation activity. Recombinant NS5 proteins of West Nile virus and De...
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It has previously been shown that incubation of mammalian cell cytosolic extracts with the protein kinase inhibitor tyrphostin A25 results in enhanced transfer of methyl groups from S-adenosyl-[methyl-3H]methionine to proteins. These findings were interpreted as demonstrating tyrphostin stimulation of a novel type of protein carboxyl methyltransferase. We find here, however, that tyrphostin A25...
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The Sn atom in the title compound, [Sn(C(4)H(9))(2)(C(7)H(5)O(3))(2)], is chelated by the carboxyl-ate groups of 2-hydroxy-benzoate liagnds, and exists in a six-coordinate skew-trapezoidal bipyramidal coordination geometry [C-Sn-C = 140.1 (3)°].
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The Sn(IV) atom in the centrosymmetric dinuclear title compound, [Sn(2)(C(4)H(9))(4)(C(7)H(3)NO(4))(2)(H(2)O)(2)], exists in a trans-C(2)SnNO(4) penta-gonal-bipyramidal geometry. There are two half-mol-ecules in the asymmetric unit that are completed by inversion symmetry. The crystal studied was a non-merohedral twin with a ratio of 47.3 (1)% for the minor twin component. Bond dimensions are s...
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The 7-methylguanosine cap added to the 5' end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs in all eukaryotic organisms in which it has been investigated. In some experimental systems, cap methylation has also been demonstrated to promote transcription, splicing, polyadenylation and...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.220.2